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KMID : 0359720180360040329
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Journal of the Korean Neurological Association
2018 Volume.36 No. 4 p.329 ~ p.332
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Rituximab Treatment for Polyneuropathy Induced by an Immune Checkpoint Inhibitor
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Shin Hye-Rim
Kang Dong-Wan
Kim Eun-Young
Kim Tae-Min
Lee Soon-Tae
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Abstract
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Immune checkpoint inhibitor is associated with variety of immune-related adverse events. We present a case of polyneuropathy induced by immune checkpoint inhibitor, which was refractory to steroid and immunoglobulin. While high-dose steroid and immunoglobulin were not effective, we tried rituximab which is effective in other immune-mediated polyneuropathy. After rituximab treatment, patient’s clinical symptom and nerve conduction study finding was markedly improved. We suggest rituximab might be effective in polyneuropathy induced by immune checkpoint inhibitor.
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KEYWORD
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Autoimmune diseases, Polyneuropathies, Rituximab
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